Ear wax odor may provide an early warning sign for Parkinson’s disease
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Ear wax may provide unexpected early warnings Parkinson’s disease (PD), according to a new study.
In particular, the odor may help clinicians detect progressive neuromotility disorders, the researchers state in the study, which is published in the Journal Analytical Chemistry.
Health experts say Parkinsons are usually diagnosed after an individual has symptoms such as tremor, stiffness, bradykinesia (slow movement), and changes in walking.
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This study suggested that volatile organic compounds (VOCs) – sebum (an oily secretions that help to lubricate and protect the skin). Ear wax Parkinson’s individual – has a certain unique smell.
Odor is the result of systemic inflammation, neurodegeneration, and oxidative stress associated with disease progression, as described in the American Chemical Society report.
According to a new study, ear waxes can provide an unexpected early warning for Parkinson’s disease. (istock)
“There is evidence that patients with Parkinson’s disease produce excess sebum, and other research groups have demonstrated that there is a specific chemical profile of this sebum compared to patients without PD,” says Dr. Johi Jimenez-Shahed. Movement disorderNeuroregulation and brain circuit therapies at Icahn School of Medicine in Mount Sinai, New York City, told Fox News Digital.
(Jimenez-Shahed was not affiliated with this study.)
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In this recent study, Chinese researchers analyzed the wax and carefully crafted its ear canals of 209 participants, of which 108 were diagnosed with Parkinson’s disease.
Using a specialized method for analyzing chemicals in wax, investigators found that four of the VOCs in people with this disease were significantly different from those with undiagnosed.
This study suggests that volatile organic compounds (VOCs) released by sebum (fatty secretions) in the wax of the ears of people with Parkinson’s disease have a certain unique smell. (istock)
They concluded that four VOCs (ethylbenzene, 4-ethyltoluene, pentagonal, 2-pentadecyl-1,3-dioxolane) could function as. Potential biomarkers For PD.
Using collected ear wax data, researchers trained an artificial intelligence olfactory (AIO) system and used sensors to simulate human odor sensations to detect and analyze VOCs.
According to the report, the AIO system showed 94% accuracy using ear wax samples with or without Parkinson’s disease.
The research authors suggested that AIO systems could ultimately be used as first choice Screening Tools It allows early treatment of the disease for early Parkinson detection.
Health experts say Parkinsons are usually diagnosed after an individual has symptoms such as tremor, stiffness, bradykinesia (slow movement), and changes in walking. (istock)
Most current treatments help manage symptoms and maintain quality of life, but do not stop or reverse the illness. Neuropathy and stroke (nindo).
The report also noted that current tests of Parkinson’s disease, such as imaging studies and clinical rating scales, could be expensive and subjective.
This potential detection system could provide an easy and inexpensive way to test disease, but experts pointed out that more testing is needed.
Limitations and future research
According to Hao Dong, one of the research authors of the Frontier Fundamental Research Research Center in China, the study was conducted on a small scale in a single clinic in China.
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“The next step is to conduct further research among different stages of the disease, multiple research centres and multiple ethnic groups to determine whether this method has a larger practical application value,” Don said in a news release.
Jimenez-Shahed ideally, this new method could serve as an early diagnostic test, spinal fluid, skin biopsy or Specialist scan.
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The above expert, who is also an associate professor of neurology and neurosurgery at Icahn School of Medicine in Mount Sinai, warned that the specific profile of ear wax VOCs reported in recent studies may differ from the findings of other studies.
“Replication and extension of sample sizes is required before determining the possibility of a particular diagnosis of such a test,” he added.
Those concerned about potential Parkinson’s risk should consult a neurologist or a motor disorder specialist, advised Jimenez Shahed.
Experts can carefully screen early warning signs and explain them in more detail Diagnostic test Or treatment.
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This research was funded by the National Natural Science Foundation of Zejiang Province, Pioneer and the major Goose R&D programmes, and the Fundamental Research Fund of Central University.
Fox News Digital has contacted the study authors for further comment.